sequel of Group A Beta hemolytic streptococcal ,upper respiratory
tract infection, age 5-15 yrs, and young adults, 3% of these
get Acute Rheumatic Fever. The pathogenic mechanism is unknown.
But the most widely held view is that it is due to autoimmune,
immunologic response to either extracellular or somatic antigen
of group A beta hemolytic streptococcus. It runs in families.
Prior Infection with Group A, beta hemolytic streptococcus
2) pancarditis including
MR (mitral regurgitation) and AI (aortic insufficiency)
3) migratory arthritis
(inflammation of various joints)
4) erythema marginatum
5) subcutaneous nodules
6) Chorea (involuntary
movements of extremities)
7) increased anti streptolysin
O titer (blood test of an antibody against the streptococcus
group A beta hemolytic type.
of beta hemolytic group A infection consists of penicillin and
long term penicillin prophylaxis